The median radiation dose was 35 Gy (range, 6-45 Gy). T classification included T1, 40 patients (71%) T2, 12 patients (21%) and T3, 4 patients (7%). Results: Fifty-six patients met the eligibility criteria, and 63 tumorsmore » were treated: head and neck (27%), trunk (14%), upper extremities (27%), and lower extremities (32%). Radiation therapy was delivered at 8 participating International Lymphoma Radiation Oncology Group institutions worldwide. Data collected include initial stage of disease, RT modality (electron/photon), total dose, fractionation, response to treatment, and local recurrence. Methods and Materials: The study was a retrospective analysis of patients with primary cutaneous anaplastic large cell lymphoma who received RT as primary therapy or after surgical excision. Purpose: To collect response rates of primary cutaneous anaplastic large cell lymphoma, a rare cutaneous T-cell lymphoma, to radiation therapy (RT), and to determine potential prognostic factors predictive of outcome. Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: An International Lymphoma Radiation Oncology Group Multi-institutional ExperienceĭOE Office of Scientific and Technical Information (OSTI.GOV) Misdiagnosis can lead to inappropriate therapy and result in disease progression or unnecessary harm to the patient. Lessons: C-ALCL is a rare type of cancer. During the 5-year follow-up, no recurrence occurred. Outcomes: After 4 cycles of chemotherapy, a complete remission of skin lesions was achieved. Interventions: The patient was transferred to the Lymphoid Tumours Clinic of the Maria SkÅ‚odowska Curie Memorial Cancer Centre and Institute of Oncology in Warsaw, where chemotherapy was initiated. Because of the discrepancy between clinical and histopathological findings, the tumor specimen was submitted to another facility, wherein lymphoma infiltration by anaplastic large cells was found in the dermis and subcutaneous tissue. Histopathological examination revealed the presence of pilomatrix carcinoma (trichilemmal carcinoma). During treatment for discoid lupus erythematosus, biopsy was repeated because of significant disease progression and dynamic tumor growth. Patient concerns: This is the case of a 73-year-old man who reported to the Clinic of Cranio-Maxillofacial and Oral Surgery and Implantology, Medical University of Warsaw, owing to a skin tumor in the right parotideomasseteric region, initially diagnosed as discoid lupus erythematosus. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface. Primary cutaneous anaplastic large-cell lymphoma: A case reportĪbed, Kamil Stopa, Zygmunt Siewert-Gutowska, MartaĪbstract Rationale: Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. This case provides an example of solid primary effusion lymphoma mimicking cutaneous anaplastic large T-cell lymphoma and highlights the importance of HHV8 immunohistochemistry and molecular tests in the diagnosis of HHV8-associated lymphoma with a cutaneous presentation. Cutaneous anaplastic large T-cell lymphoma was initially diagnosed, but further tests, including immunoreactivity for HHV8 protein and clonal rearrangements of immunoglobulin genes, confirmed the diagnosis of HHV8-associated B-cell lymphoma with aberrant T-cell marker expression. These malignant cells strongly expressed CD3, CD30 and CD43. Biopsy of the nodules showed anaplastic large cells infiltrating the dermis. The patient was a 31-year-old HIV-seropositive man presenting with skin nodules over his right thigh. We report a case of HHV8-associated lymphoma histopathologically and immunophenotypically mimicking cutaneous anaplastic large cell lymphoma. This suggests the solid variant may represent a clinicopathological spectrum of primary effusion lymphoma. They have similar clinical, histopathological and immunophenotypical features. It presents as a body cavity-based lymphomatous effusion, but several cases of the so-called solid primary effusion lymphoma presenting as solid tumors without associated lymphomatous effusion have been reported. Primary effusion lymphoma, a human herpesvirus 8 (HHV8)-associated lymphoma, is uncommon, and it is usually seen in human immunodeficiency virus (HIV)-infected patients. Li, Meng-Fang Hsiao, Cheng-Hsiang Chen, Yi-Lin Huang, Wen-Ya Lee, Yi-Hsuan Huang, Hsien-Neng Lien, Huang-Chun Human herpesvirus 8-associated lymphoma mimicking cutaneous anaplastic large T-cell lymphoma in a patient with human immunodeficiency virus infection.
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